Disorders of Metals and Metalloproteins

Arie Drugan, Mark Paul Johnson, and Mark I. Evans

Metals constitute an integral part of some important enzymes and as such are essential for human development an health. Disease may result either from absence of the specific metal or from excess metal being available, leading to toxic accumulation in tissues. Abnormal metabolism of metal elements leading to human disease has been described mainly for copper and iron. Molybdenum cofactor deficiency is also discussed in this chapter...